Depression

• According to aafp.org, benzodiazepine use increases the risk of emotional blunting and suicidal ideation in some users, though these risks are usually associated with higher doses. Depression is also a common side effect among people who abuse alcohol.
  
  

Addiction and Withdrawal

• Depressants like Xanax and alcohol have a high potential for abuse and dependence. When stopped abruptly, they can cause dangerous withdrawal symptoms, including seizure, coma and death, according to gdcada.org.
  
  

Cognitive Impairment

• Long-term use of depressants can cause cognitive impairment in some people. Memory loss, inhibited problem-solving skills and changes in mood and behavior are possible outcomes of depressant use.
  
  

Overdose

• As tolerance increases, higher doses are needed to produce desired effects, increasing the likelihood of overdose. As with most depressants, the amount needed to induce calmness and sedation can be dangerously close to the lethal dose.
  
  

Warning

• Taking more than one depressant drug increases the chance of fatal respiratory depression and cardiac arrest. Avoid driving and other potentially dangerous tasks while under the influence of depressants.